Cov dej noo ntawm cov khoom, kev ua haujlwm ntawm lyophilizer, tswj lub sijhawm ntawm kev tshuaj xyuas kom qhuav thiab qhov kub ntawm kev tshuaj ziab ziab yog qhov tseem ceeb cuam tshuam rau ya raws. Rau cov khoom khov-qhuav, cov dej yuav tsum yog ≤ 3%. Cov dej siab cov ntsiab lus ntawm cov khoom khov-qhuav yuav decompose thiab ntsws cov khoom. Qhov laj thawj tseem ceeb rau cov ntsiab lus dej siab ntawm cov khoom yog:
1. Cov tshuaj kua ntau dhau. Lub tuab ntawm cov tshuaj ua kua ntim ntim feem ntau yog 10-15 hli, uas yuav tsum tsis pub tshaj 15 hli. Yog tias qhov ntim puv loj, nws tuaj yeem txiav txim siab hloov cov ntim nrog cov lus qhia tshwj xeeb kom txo cov tuab ntawm cov tshuaj kua. Cov kua ua kua ntau dhau yuav ua rau cov cua sov hloov pauv mus rau qhov txheej txheem kom qhuav, uas tsis zoo rau tshem cov dej hauv cov khoom, thiab cov dej hauv cov khoom yog siab dhau.
2. Cov khoom qhuav tau nqus dej dua. Rau ntau yam uas yooj yim nqus dej noo, yog tias lawv tsis ua haujlwm zoo tom qab ziab, cov khoom lag luam yuav nqus dej noo dua, ua kom cov dej muaj nyob hauv cov khoom. Yog tias cov pa nkag mus rau hauv lub thawv txias kom qhuav thaum lub qhov cua, nws yog qhov yuav tsum tau kom tsis muaj menyuam, lim thiab ua kom cov pa nkag mus rau hauv lub tshuab khov kom qhuav; Qhov kub ntawm cov khoom thaum nws tawm ntawm lub thawv tseem yuav cuam tshuam rau cov dej cov ntsiab lus ntawm cov khoom. Yog li ntawd, qhov kub ntawm cov khoom thaum nws tawm ntawm lub thawv siab dua li ntawm chav huv kom tiv thaiv ya raws hauv huab cua los ntawm hws rau ntawm cov khoom. Ib qho ntxiv, cov av noo txheeb ze ntawm chav huv yuav tsum tau tswj nruj me ntsis qis dua 50%.
Cov tsos ntawm cov khoom lag luam thiab cov tsos ntawm cov khoom khov-qhuav yog cuam tshuam nrog kev khov-ziab nkhaus ua tiav!
Cov kev qhia tshwj xeeb ntawm cov khoom tsis zoo ntawm cov khoom khov-qhuav yog ntsws, crystallization, tsis txaus flocculent, thiab lwm yam. thiab nce tus nqi tsim khoom. Yam uas cuam tshuam rau qhov pom ntawm cov khoom suav nrog:
1. Cov txiaj ntsig ntawm qhov siab lossis qis cov ntsiab lus nyob rau saum npoo ntawm cov tshuaj suav daws hauv cov txheej txheem ntawm kev npaj thiab ziab. Thaum cov tshuaj daws siab ntau dhau:
Nws tau qhuav kom tsim tau qhov ntom ntom. Cov txheej saum npoo av muaj qhov hws me me thiab huab cua tsis zoo nkag mus, thiab cov dej hauv nws nyuaj dhau los ntawm txheej txheej, yog li nws nce raws lub raj mis phab ntsa, ua rau cov khoom tawm ntawm phab ntsa thiab ntsws; Ib qho ntxiv, thaum cov ntsiab lus siab dhau, cov tshuaj ua kua tau yooj yim rau agglomerate thaum khov-ziab, thiab cov tsos ntawm cov khoom tsis sib xws. Thaum qhov kev ntsuas qis dhau: cov khoom siv dag zog muaj tsawg, thiab cov qauv khoom lag luam kuj tseem xoob lossis txawm tias dhau los ua hmoov tom qab ntim thiab thauj mus los, uas cuam tshuam rau qhov pom ntawm cov khoom.
2. Cov khoom tuab tuab heev. Feem ntau, nws yuav tsum yog 10-15 hli. Yog tias cov khoom lag luam tuab dhau, nws zoo ib yam li rooj plaub thaum lub siab ntau dhau, tsis tsuas yog lub sijhawm ziab kom qhuav ntev dua, tab sis kuj tseem tawg thiab ci.
3. Qhov kub thiab txias nce sai, thiab nws yooj yim ua rau cov khoom tawm ntawm phab ntsa thiab qeeb. Ua ntej khov ceev: cov khoom lag luam nrog qhov kub poob ntawm 10-15 ℃ ib feeb yog hu ua khov sai, thiab cov khoom lag luam nrog qhov ntsuas kub poob ntawm 1 ℃ toj ib teev hauv ib feeb thaum lub sijhawm khov txheej txheem khov tshuab hu ua khov khov. Feem ntau, ib-theem sublimation kom qhuav: cov khoom kub yuav tsum raug txo thiab qhov txias yuav tsum tau tswj ntawm 5-6 ℃.
Hauv qab lub ntsiab lus eutectic, qhov kub nce yuav tsum qeeb, nyiam dua 5 ℃ toj ib teev, thiab ntau dua 90% ntawm cov dej yuav tsum raug tshem tawm thaum kawg ntawm theem kuv sublimation kom qhuav. Theem thib ob sublimation kom qhuav: theem no feem ntau yog tshem tawm cov dej siv lead ua thiab cov dej nqus tau. Cov cua sov tuaj yeem ua kom nrawm dua, nyiam dua 5-10 ℃ / h, tab sis Zui qhov khoom kawg qhov kub tsis tuaj yeem tshaj qhov ntsuas kub nyab xeeb ntawm cov khoom, txwv tsis pub cov haujlwm ntawm cov khoom yuav raug txo qis, ci thiab tsis ua haujlwm tau zoo.
4.Lub cev ntaj ntsug. Ua ntej tawm los ntawm lub txee, cov ntshav los ntshav yuav tsum tsis txhob nrawm dhau, txwv tsis pub lub tshuab nqus tsev hauv lub thawv yuav hloov pauv sai heev, thiab cov dej ntws tsis txaus yuav tsim kom maj mus rau hauv lub thawv, ua rau cov khoom ua kua dej los yog hmoov, cuam tshuam cov tsos.
