Kev txhais lus ntawm ntau qhov yuav tsum tau ua ntawm kws tshuaj lyophilizer rau ntim ntim
Cov khoom lag luam ua tiav los ntawm lub tshuab nqus tsev khov- ziab ntawm cov tshuaj khov kho- tshuab ziab khaub ncaws yooj yim khaws cia rau lub sijhawm ntev. Tom qab ntxiv dej, lawv tuaj yeem rov qab mus rau lub xeev ua ntej khov - kom qhuav thiab tuav cov yam ntxwv ntawm biochemical qub. Lub freeze- tshuab ziab khaub ncaws yog qhov tsim nyog rau cov cua sov- cov khoom rhiab heev xws li tshuaj tua kab mob, tshuaj tiv thaiv, cov khoom siv ntshav, enzymes, cov tshuaj hormones, thiab lwm yam kab mob lom. Nws yog dav siv nyob rau hauv kev lag luam tshuaj, chaw muag tshuaj, kev tshawb fawb lom neeg, tshuaj lom neeg kev lag luam, khoom noj khoom haus, thiab lwm yam.
Txawm hais tias biopharmaceutical yog ib ceg me me ntawm kev lag luam tshuaj, nws qhov tseem ceeb tau nce zuj zus nyob rau ib hnub. Cov tshuaj lom neeg yog cov tshuaj bioactive, tshwj xeeb tshaj yog rau qhov kub thiab txias, tsis ruaj khov, thiab yooj yim rau kev sib cuag nrog ib leeg. Vim yog cov yam ntxwv saum toj no, lub neej cia ntawm cov tshuaj lom neeg yog luv heev, thiab lawv feem ntau yuav tsum tau khov, txwv tsis pub, lawv yuav deteriorate sai. Yog li dab tsi ntawm cov ntim yuav tsum tau siv rau cov tshuaj lom neeg ua los ntawm cov kws kho mob khov- tshuab ziab khaub ncaws los ntawm khov- txoj kev ziab?
1. Thaum tshav kub kub kev ua haujlwm
Kev ua tiav ntawm khov- ziab yog nyob ntawm qhov ua tau zoo ntawm kev ua kom sov ntawm lub thawv. Vim li no, cov thawv ntim khoom siv rau hauv khov- txheej txheem ziab yuav tsum ua tau raws li cov hauv qab no: lawv yuav tsum tau ua los ntawm cov ntaub ntawv uas muaj peev xwm muab tau zoo thermal conductivity, thiab qhov tsis muaj zog ntawm thermal rwb thaiv tsev ntawm lub thawv, zoo dua; Yuav kom txuag tau lub zog, lub thawv yuav tsum muaj kev hloov pauv hluav taws xob siab thiab tuaj yeem hloov tau cov cua sov uas tsim los ntawm lub txee ntawm lyophilizer rau lub thawv.
Cov thawv ua los ntawm cov ntaub ntawv uas tsis tshua muaj hluav taws xob hloov pauv coefficient muaj qhov ua tau zoo ntawm cov cua sov tsawg; Cov duab, qhov loj me, lossis qhov zoo ntawm lub thawv yuav cuam tshuam rau kev hloov hluav taws xob ntawm lub thawv; Yog tias siv cov khoom siv ntau dhau los ntawm kev tsim cov thawv ntim khoom, cov ntaub ntawv no yuav dhau los ua lub thermal barrier los tiv thaiv lub zog los ntawm kev xa mus rau hauv lub thawv. Tsawg thermal conductivity feem ntau ua rau tsis ua haujlwm ntawm khov - ziab ntawm cov khoom.
Lub sublimation nto yuav cia li tig mus rau hauv qab ntawm lub thawv ntim, thiab lyophilizer yuav txav mus rau sab hauv ntawm qhov chaw ntawm lub cev khov. Yog tias lub thawv muaj qhov pom tseeb thermal rwb thaiv tsev, tag nrho cov txheej txheem sublimation tsis tuaj yeem tswj tau; Yog tias cov txheej txheem sublimation tsis tswj hwm, qee cov tshuaj yuav tsum nqus kom qhuav es tsis txhob khov -qhuav. Cov tshuaj ua tiav hauv txoj kev no tsis muaj nws qhov kev ua tau zoo. Kev saib xyuas ntawm nws cov dej num, txee lub neej, thiab kev hloov kho sai yuav raug txo kom tsawg.
2. sealing kev ua tau zoo
Nyob rau theem tom ntej ntawm kev khov- ua kom qhuav, tus neeg sawv cev tau khov- ziab los ntawm khov- tshuab ziab khaub ncaws, thiab cov cuab yeej yuav tsim ib qho chaw ultra- qhuav . Ua ntej noj lub thawv ntim tshuaj tawm ntawm qhov chaw ultra- qhuav, lub thawv yuav tsum tau muab kaw. Qhov no yog vim hais tias tom qab ziab, cov seem seem ntawm tus neeg sawv cev raug txo kom tsawg dua 3 feem pua. Thaum raug rau sab nraud ib puag ncig nrog cov av noo ntau dua li nws tus kheej, qhov khov - ziab yuav nqus dej los ntawm ib puag ncig sab nraud kom ntau li ntau tau. Thaum cov tshuaj absorbs dej, qhov zoo yuav deteriorate tam sim ntawd; Kev ua haujlwm ntawm khov - tus neeg ua kom qhuav yuav tsis muaj zog. Lub reabsorption ntawm cov dej los ntawm tus neeg sawv cev yuav ua rau poob ntawm kev ua tau zoo ntawm tus neeg saib xyuas, uas yuav tsis ua tiav cov kev xav tau kev kho mob, thiab txawm ua rau cov neeg tsim khoom yuav tsum rov qab cov khoom.
Kev siv cov ntim uas tsis tuaj yeem muab ntim rau hauv lyophilizer yog ib qho yuam kev ua los ntawm cov tuam txhab tshuaj lom neeg. Piv txwv li, ntau cov tshuaj ntsuam xyuas tau ntim rau hauv cov raj kuaj kom khov - ua kom qhuav hauv qhov khov - tshuab ziab khaub ncaws. Cov raj no tau muab kaw nrog lub hau ntswj. Tam sim no tsis muaj txoj hauv kev los kaw cov raj ntsuas no hauv qhov khov - tshuab ziab khaub ncaws, yog li cov tuam ntxhab yuav tsum sib sau ua ke ntau pab pawg neeg ua haujlwm los kaw cov ntim khoom manually. Cov txheej txheem no feem ntau yog ua nyob rau hauv ib lub rhiav uas tsis tau raws li lub freeze -kev ua kom qhuav cov kev cai ntawm khov- tshuab ziab khaub ncaws. Nyob rau hauv txoj kev no, tus neeg saib xyuas cia li khov-qhuav los ntawm qhov khov- tshuab ziab khaub ncaws yuav raug rau ib puag ncig nrog cov av noo siab, tus neeg saib xyuas yuav nqus dej ntau hauv ib puag ncig, thiab nws qhov kev ua tau zoo yuav tsis ruaj khov.
